Broad Review of FDA Trials Suggests Antidepressants Only Marginally Better than Placebo

In addition to reporting on low efficacy of antidepressants compared with placebo, the 4 meta-analyses "also document a second form of bias in which researchers fail to report the negative results for the prespecified primary outcome measure submitted to the FDA, while highlighting in published studies positive results from a secondary or even a new measure, as though it was their primary measure of interest," the investigators write.

BIG surprise, huh. Skewing results for approval.